1: With potassium hydrogen fluoride in methanol; water 0.5 h; 2: With chloro-trimethyl-silane; water in acetonitrile 1 h;

1.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tripotassium phosphate monohydrate; palladium diacetate / toluene 2.1: 10 palladium on activated charcoal; hydrogen / ethanol 3.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 4.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 5.1: potassium hydrogen fluoride / methanol; water / 0.5 h 5.2: 1 h View Scheme

1.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tripotassium phosphate monohydrate; palladium diacetate / toluene 2.1: 10 palladium on activated charcoal; hydrogen / ethanol 3.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 4.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 5.1: potassium hydrogen fluoride / methanol; water / 0.5 h 5.2: 1 h View Scheme

1.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 3.1: potassium hydrogen fluoride / methanol; water / 0.5 h 3.2: 1 h View Scheme

1.1: 10 palladium on activated charcoal; hydrogen / ethanol 2.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 3.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 4.1: potassium hydrogen fluoride / methanol; water / 0.5 h 4.2: 1 h View Scheme

1.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 2.1: potassium hydrogen fluoride / methanol; water / 0.5 h 2.2: 1 h View Scheme

sodium carbonate in water; ethyl acetate; isopropyl alcohol T=50°C; Suzuki-Miyaura coupling; 0.00138889 h; Microchannel flow reactor;

1.1: lithium hydroxide hydrate; tris-(dibenzylideneacetone)dipalladium(0) / water; 1-methyl-pyrrolidin-2-one / 24 h / 65 °C / |Inert atmosphere; |Schlenk technique 2.1: palladium diacetate; N-acetyl-glycine; potassium acetate; [bis(acetoxy)iodo]benzene / tert-butyl alcohol / 12 h / 80 °C / |Sealed tube 3.1: sodium methylate / tetrahydrofuran / 1 h / 35 °C / |Cooling with ice 3.2: 45 °C 3.3: 6 h / 55 °C 4.1: palladium diacetate; N-acetyl-glycine; potassium acetate; [bis(acetoxy)iodo]benzene / tert-butyl alcohol / 12 h / 100 °C / |Sealed tube View Scheme

water; sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether 0.5 h; Heating;

water; sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether 0.5 h; Heating;