1: 2-chloro-pyrazine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-76 - 0°C; 1.25 h; 2: formic acid ethyl ester in tetrahydrofuran; hexane T=-70°C; 1.5 h; 3: With acetic acid in tetrahydrofuran; hexane T=-70°C;

1: 2-chloro-pyrazine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; 1.13333 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 0°C; 0.8 h;

1: 2-chloro-pyrazine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 1 h; 2: formic acid methyl ester in tetrahydrofuran; hexanes T=-78°C; 2.25 h; 3: With acetic acid in tetrahydrofuran; hexanes T=-78 - 0°C;

2,2,6,6-tetramethylpiperidinyl-lithium 1.) hexane, THF, -70 deg C, 30 min, 2.) -70 deg C, 1.5 h; Yield given. Multistep reaction;