1.2-二氟-3-乙酰甲基-4-硝基苯合成路线 (共 7 条)
反应条件
hydrogenchloride; acetic acid in tetrahydrofuran; water
参考文献
Wakunaga Seiyaku Kabushiki Kaisha; Fujisawa Pharmaceutical Co., Ltd.
Patent: US5254685 A1, 1993 ;
反应条件
acetic acid in tetrahydrofuran; hydrogenchloride
反应条件
hydrogenchloride; acetic acid 12 h; Heating / reflux;
参考文献
Qian, Changgeng; Cai, Xiong; Zhai, Haixiao
Patent: US2009/76044 A1, 2009 ;
Location in patent: Page/Page column 27 ;
US 20090076044 A1
参考文献
WO2004/9542 A2, ;
Page 26 ;
WO 2004/009542 A2
反应条件
potassium carbonate in methanol 3 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/9542 A2, 2004 ;
Location in patent: Page 34; 35 ;
WO 2004/009542 A2
反应条件
lithium hydroxide T=100 - 110°C; 4 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/9542 A2, 2004 ;
Location in patent: Page 35; 36 ;
WO 2004/009542 A2
反应条件
sodium acetate in N,N-dimethyl-formamide T=100°C; 12 h;
参考文献
Qian, Changgeng; Cai, Xiong; Zhai, Haixiao
Patent: US2009/76044 A1, 2009 ;
Location in patent: Page/Page column 27-28 ;
US 20090076044 A1