2-羟基环己基氨基甲酸叔丁酯合成路线 （共 21 条）
反应条件
ethanol; palladium on activated charcoal in cyclohexene 6 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/83174 A2, 2004 ;
Location in patent: Page 172 ;
WO 2004/083174 A2
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; 10 h;
参考文献
Quijada, F. Javier; Rebolledo, Francisca; Gotor, Vicente
Tetrahedron, 2012 , vol. 68, # 37 p. 7670 - 7674
反应条件
triethylamine in dichloromethane T=20°C; 2 h;
参考文献
ARRAY BIOPHARMA INC.; ANDREWS, Steven W.; CONDROSKI, Kevin Ronald; DE MEESE, Lisa A.; FELL, Jay Bradford; FISCHER, John P.; LE HUEROU, Yvan; JOSEY, John A.; KOCH, Kevin; MIKNIS, Gregory F.; RODRIGUEZ, Martha E.; TOPALOV, George T.; WALLACE, Eli M.; XU, Rui
Patent: WO2011/29027 A1, 2011 ;
Location in patent: Page/Page column 130; 131 ;
WO 2011/029027 A1
反应条件
hydrogen; platinum(IV) oxide in ethyl acetate T=20°C; P=1810.02 - 2068.59 Torr;
参考文献
Journal of Organic Chemistry, , vol. 69, # 6 p. 1858 - 1865
反应条件
potassium hydrogencarbonate in diethyl ether; water 96 h; Ambient temperature;
参考文献
Aube; Wolfe; Yantiss; Cook; Takusagawa
Synthetic Communications, 1992 , vol. 22, # 20 p. 3003 - 3012
反应条件
1: 100 percent / Et3N / tetrahydrofuran 2: 96 percent / H2 / Pd-C / ethanol / 6 h / 1292.9 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 16 p. 4419 - 4427
反应条件
sodium hydrogencarbonate in dichloromethane
参考文献
Merck and Co., Inc.
Patent: US6043358 A1, 2000 ;
反应条件
1: MeONa / methanol 2: H2 / PtO2 / ethyl acetate / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 6 p. 1858 - 1865
反应条件
1: H2 / PtO2 / ethyl acetate / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr 2: ethyl acetate View Scheme
参考文献
Organic Letters, , vol. 5, # 17 p. 3013 - 3016
反应条件
1: NaN3; NH4Cl / aq. ethanol / 18 h / Heating 2: pyridine; DMAP / 16 h / 20 °C 3: lipase Amano-PS; aq. phosphate buffer / 2.5 h / pH 7.2 4: MeONa / methanol 5: H2 / PtO2 / ethyl acetate / 20 °C / 1810.02 - 2068.59 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 6 p. 1858 - 1865
