3-甲基氨基-4,4,4-三氟丁烯酸乙酯合成路线 （共 2 条）
反应条件
1: ethyl-α,α,α-trifluoroacetate; ethyl acetate With sodium ethanolate T=20 - 76°C; 5 h; 2: methylamine in cyclohexane; water 4 - 5 h; Heating / reflux;
参考文献
DEGUSSA AG
Patent: WO2004/16579 A1, 2004 ;
Location in patent: Page 7-9 ;
反应条件
1: 3-methylamino-4,4,4-trifluorocrotonic acid ethyl ester With potassium tert-butylate in N,N-dimethyl-formamide
T=40 - 45°C; 0.583333 h;
2: N-(2-chloro-4-fluoro-5-isocyanatobenzoyl)-N'-methyl-(1-methylethyl)sulfamide in N,N-dimethyl-formamide
T=-15 - 22°C;
参考文献
Schmidt, Thomas; Gebhardt, Joachim; Loehr, Sandra; Keil, Michael; Wevers, Jan Hendrik; Erk, Peter; Saxell, Heidi Emilia; Hamprecht, Gerhard; Mayer, Guido; Wolf, Bernd; Cox, Gerhard; Michel, Alfred; Seitz, Werner; Zagar, Cyrill; Reinhard, Robert; Sievernich, Bernd
Patent: US2010/35905 A1, 2010 ;
Location in patent: Page/Page column 7 ;
