(R)-1-氨基-2,3-二氢-1H-茚-4-甲腈盐酸盐合成路线 （共 3 条）
反应条件
sodium hydrogencarbonate in dichloromethane; water
参考文献
RECEPTOS, INC.; MARTINBOROUGH, Esther; BOEHM, Marcus, F.; YEAGER, Adam, Richard; TAMIYA, Junko; HUANG, Liming; BRAHMACHARY, Enugurthi; MOORJANI, Manisha
Patent: WO2011/60389 A1, 2011 ;
Location in patent: Page/Page column 91-92 ;
WO 2011/060389 A1
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / 1-methyl-pyrrolidin-2-one / 7 h / 95 °C / Inert atmosphere 2: titanium tetraethoxide / toluene / 12 h / 60 °C / Inert atmosphere 3: sodium tetrahydroborate; tetrahydrofuran / 2.5 h / -78 - 0 °C / Inert atmosphere 4: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C 5: sodium hydrogencarbonate / dichloromethane; water View Scheme
参考文献
RECEPTOS, INC.; MARTINBOROUGH, Esther; BOEHM, Marcus, F.; YEAGER, Adam, Richard; TAMIYA, Junko; HUANG, Liming; BRAHMACHARY, Enugurthi; MOORJANI, Manisha
Patent: WO2011/60389 A1, 2011 ;
WO 2011/060389 A1
反应条件
1: titanium tetraethoxide / toluene / 12 h / 60 °C / Inert atmosphere 2: sodium tetrahydroborate; tetrahydrofuran / 2.5 h / -78 - 0 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C 4: sodium hydrogencarbonate / dichloromethane; water View Scheme
参考文献
RECEPTOS, INC.; MARTINBOROUGH, Esther; BOEHM, Marcus, F.; YEAGER, Adam, Richard; TAMIYA, Junko; HUANG, Liming; BRAHMACHARY, Enugurthi; MOORJANI, Manisha
Patent: WO2011/60389 A1, 2011 ;
WO 2011/060389 A1
