WZ 4002; N-[3-[[5-氯-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氧基]苯基]-2-丙烯酰胺合成路线 （共 7 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0°C; 1 h;
参考文献
WO2010/129053 A2, ;
Page/Page column 124-125 ;
WO 2010/129053 A2
反应条件
1: trifluoroacetic acid / Sec-butyl alcohol / 100 °C 2: platinum(IV) oxide; hydrogen / methanol 3: N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 2 p. 638 - 643
反应条件
1: trifluoroacetic acid / Sec-butyl alcohol / 100 °C 2: platinum(IV) oxide; hydrogen / methanol 3: N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 2 p. 638 - 643
反应条件
1: potassium carbonate / N,N-dimethyl-formamide 2: trifluoroacetic acid / Sec-butyl alcohol / 100 °C 3: platinum(IV) oxide; hydrogen / methanol 4: N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 2 p. 638 - 643
反应条件
1: platinum(IV) oxide; hydrogen / methanol 2: N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 2 p. 638 - 643
反应条件
1: potassium carbonate / acetone / 4 h / |Reflux 2: potassium carbonate / dimethyl sulfoxide / 20 °C 3: iron; ammonium chloride / tetrahydrofuran; water / 3 h / |Reflux 4: trifluoroacetic acid / Sec-butyl alcohol / 3 h / |Reflux 5: iron; ammonium chloride / tetrahydrofuran; water / 3 h / |Reflux 6: triethylamine / dichloromethane / 1 h / 0 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 77, p. 75 - 83
反应条件
1: potassium carbonate / dimethyl sulfoxide / 20 °C 2: iron; ammonium chloride / tetrahydrofuran; water / 3 h / |Reflux 3: trifluoroacetic acid / Sec-butyl alcohol / 3 h / |Reflux 4: iron; ammonium chloride / tetrahydrofuran; water / 3 h / |Reflux 5: triethylamine / dichloromethane / 1 h / 0 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 77, p. 75 - 83
