water; potassium hydroxide in tetrahydrofuran T=20°C; 2 h;

1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; methanol / 4 h / 70 °C / |Inert atmosphere 2: potassium hydroxide; water / tetrahydrofuran / 2 h / 20 °C View Scheme

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C 1.2: 20 °C 2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; methanol / 4 h / 70 °C / |Inert atmosphere 3.1: potassium hydroxide; water / tetrahydrofuran / 2 h / 20 °C View Scheme

1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; methanol / 4 h / 70 °C / |Inert atmosphere 2: potassium hydroxide; water / tetrahydrofuran / 2 h / 20 °C View Scheme