2-溴-3-硝基-5-(三氟甲基)吡啶合成路线 （共 6 条）
反应条件
1: With phosphorus oxytribromide in acetonitrile T=20°C; Reflux; 2: With sodium hydrogencarbonate in water; acetonitrile
参考文献
US2011/230483 A1, ;
Page/Page column 32 ;
反应条件
1.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 3.1: hydrogenchloride; water / 24 h / Reflux 4.1: sulfuric acid / 48 h / Reflux 4.2: 20 °C 5.1: sodium hydroxide; methanol / 0.02 h / 20 °C 5.2: pH 1 View Scheme
参考文献
NOVARTIS AG
Patent: US2011/230483 A1, 2011 ;
反应条件
tetrabutylammomium bromide in toluene
10 h; Reflux;
参考文献
NOVARTIS AG; LEGRAND, Darren Mark
Patent: WO2013/38378 A1, 2013 ;
Location in patent: Page/Page column 48-49 ;
反应条件
tetrabutylammomium bromide; copper (I) cyanide in toluene
9 h; Reflux;
参考文献
NOVARTIS AG; BALA, Kamlesh, Jagdis; BUTLER, Rebecca; COLLINGWOOD, Stephen, Paul; HALL, Edward, Charles; EDWARDS, Lee; LEGRAND, Darren, Mark; SPIEGEL, Katrin
Patent: WO2013/38386 A1, 2013 ;
Location in patent: Page/Page column 81 ;
反应条件
1.1: tetrabutylammomium bromide / toluene / 10 h / Reflux
2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere
3.1: hydrogenchloride; water / 24 h / Reflux
4.1: sulfuric acid / 48 h / Reflux
4.2: 20 °C
View Scheme
参考文献
NOVARTIS AG; LEGRAND, Darren Mark
Patent: WO2013/38373 A1, 2013 ;
Title/Abstract Full Text Show Details
NOVARTIS AG; LEGRAND, Darren Mark
Patent: WO2013/38378 A1, 2013 ;
反应条件
1.1: tetrabutylammomium bromide / toluene / 10 h / Reflux
2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere
3.1: hydrogenchloride; water / 24 h / Reflux
4.1: sulfuric acid / 48 h / Reflux
4.2: 20 °C
5.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C
View Scheme
参考文献
NOVARTIS AG; LEGRAND, Darren Mark
Patent: WO2013/38373 A1, 2013 ;
