1: With methanol; sodium hydroxide T=20°C; 0.0166667 h; 2: With hydrogenchloride in methanol; water pH=1;

1.1: phosphorus oxytribromide / acetonitrile / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 3.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 4.1: hydrogenchloride; water / 24 h / Reflux 5.1: sulfuric acid / 48 h / Reflux 5.2: 20 °C 6.1: sodium hydroxide; methanol / 0.02 h / 20 °C 6.2: pH 1 View Scheme

1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 2.1: hydrogenchloride; water / 24 h / Reflux 3.1: sulfuric acid / 48 h / Reflux 3.2: 20 °C 4.1: sodium hydroxide; methanol / 0.02 h / 20 °C 4.2: pH 1 View Scheme

1.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 18 h / Inert atmosphere 3.1: hydrogenchloride; water / 24 h / Reflux 4.1: sulfuric acid / 48 h / Reflux 4.2: 20 °C 5.1: sodium hydroxide; methanol / 0.02 h / 20 °C 5.2: pH 1 View Scheme