2-甲氧基-3-三氟甲基-5-溴吡啶合成路线 （共 2 条）
反应条件
1: With 1,3-dibromo-5,5-dimethyl-hydantoin; trifluoroacetic acid T=20°C; 18 h; Inert atmosphere; 2: With sodium hydrogencarbonate in n-heptane; ethyl acetate
参考文献
NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HÖGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frédéric; STRANG, Ross; STOWASSER, Frank; TUFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frédéric
Patent: WO2013/88404 A1, 2013 ;
Location in patent: Page/Page column 73; 74 ;
反应条件
1: methanol / 48 h / 20 °C 2: 1,3-dibromo-5,5-dimethyl-hydantoin; trifluoroacetic acid / 16 h / 20 °C View Scheme
参考文献
WO2013/57711 A1, ;
WO 2013/057711 A1
