1: 91 percent / lithium hydroxide / tetrahydrofuran; H2O / 1 h / 0 °C 2: 68 percent / 3-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / tetrahydrofuran / 12 h 3: 86 percent / H2 / 5percent Pd/C / methanol / 48 h / 760 Torr View Scheme

Multi-step reaction with 2 steps 1: 79 percent / triphenylphosphine, diethyl azodicarboxylate (DEAD), diphenylphosphoryl azide (DPPA) / tetrahydrofuran / 48 h / 20 °C2: 59 percent / HCl / 10 h / Heating  

With  lithium hydroxide in  tetrahydrofuran; water T=0°C; 1 h;   

Multi-step reaction with 2 steps 1: 91 percent / lithium hydroxide / tetrahydrofuran; H2O / 1 h / 0 °C2: 68 percent / 3-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / tetrahydrofuran / 12 h