hydrogen; palladium on activated charcoal in methanol P=760 Torr; 48 h;

Multi-step reaction with 2 steps 1: 91 percent / lithium hydroxide / tetrahydrofuran; H2O / 1 h / 0 °C2: 68 percent / 3-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / tetrahydrofuran / 12 h  

Multi-step reaction with 3 steps 1: 59 percent / HCl / 10 h / Heating2: 91 percent / lithium hydroxide / tetrahydrofuran; H2O / 1 h / 0 °C3: 68 percent / 3-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / tetrahydrofuran / 12 h  

Multi-step reaction with 4 steps 1: 79 percent / triphenylphosphine, diethyl azodicarboxylate (DEAD), diphenylphosphoryl azide (DPPA) / tetrahydrofuran / 48 h / 20 °C2: 59 percent / HCl / 10 h / Heating3: 91 percent / lithium hydroxide / tetrahydrofuran; H2O / 1 h / 0 °C4: 68 percent / 3-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / tetrahydrofuran / 12 h