1: 2-Fluorobenzyl alcohol With trifluoromethylsulfonic anhydride; bis-(phenyl)-sulfoxide; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in toluene T=-78°C; 2: sodium salt of dimethylmalonate in tetrahydrofuran; toluene T=-78 - 20°C;

in tetrahydrofuran; mineral oil

sodium methylate in methanol Alkylation; 5 h; Heating;

1: NaOH / methanol; H2O / 3 h / Heating 2: 1 h / 145 - 150 °C View Scheme

sodium hydroxide in methanol; water Hydrolysis; 3 h; Heating;