2-(2-N-Boc-N-甲基-氨基乙基)-1H-异吲哚-1,3(2H-)-二酮合成路线 （共 7 条）
反应条件
1: N-(2-tert-butoxycarbonylaminoethyl)phthalimide With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; 12 h;
参考文献
WO2005/47253 A1, ;
Page/Page column 55-56 ;
WO 2005/047253 A1
反应条件
triethylamine in methanol T=45°C;
参考文献
Organic Preparations and Procedures International, , vol. 41, # 4 p. 301 - 307
反应条件
in tetrahydrofuran; phthalimide
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 14 h;
参考文献
Synthetic Communications, , vol. 23, # 17 p. 2443 - 2449
反应条件
1: 96 percent / CH2Cl2 / 24 h / Ambient temperature 2: 80 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 14 h View Scheme
参考文献
Synthetic Communications, , vol. 23, # 17 p. 2443 - 2449
反应条件
1: water / 3 h / 100 °C 2: methanol / 36 h / 50 °C View Scheme
反应条件
hydrazine hydrate in methanol T=60°C; 4.5 h; Reflux;
参考文献
Organic Preparations and Procedures International, , vol. 41, # 4 p. 301 - 307
