反应条件
1.1: NaH / dimethylformamide / 20 °C 1.2: 75 percent / dimethylformamide / 20 °C 2.1: n-BuLi; iPr2NH / tetrahydrofuran / 1 h / -78 °C 2.2: tetrahydrofuran / -78 - 20 °C 2.3: 77 percent / 6N HCl / CH2Cl2 / 1 h / Heating 3.1: 100 percent / thionyl chloride / 1 h / Heating 4.1: n-Buli; iPr2NH / tetrahydrofuran / 0.5 h / 0 °C 4.2: tetrahydrofuran / -78 - 20 °C 5.1: 53 percent / TBAF / tetrahydrofuran; methanol / Heating 6.1: 65 percent / ammonium formate / Pd/C / methanol; tetrahydrofuran / 4 h / 40 °C View Scheme
参考文献
Mahboobi, Siavosh; Teller, Steffen; Pongratz, Herwig; Hufsky, Harald; Sellmer, Andreas; Botzki, Alexander; Uecker, Andrea; Beckers, Thomas; Baasner, Silke; Schaechtele, Christoph; Ueberall, Florian; Kassack, Matthias U.; Dove, Stefan; Boehmer, Frank-D.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 5 p. 1002 - 1018
