N-(叔丁氧基羰基)甘氨酸-N′-甲氧基-N′-甲酰胺合成路线 （共 22 条）
反应条件
4-methyl-morpholine; isobutyl chloroformate in dichloromethane T=20°C; 16 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 1 p. 65 - 77
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=0 - 20°C; 22 h;
参考文献
Journal of Organic Chemistry, , vol. 71, # 17 p. 6678 - 6681
反应条件
1: N-methylmorpholine (NMM) / CH2Cl2 / 0.08 h / -15 °C 2: N-methylmorpholine (NMM) / CH2Cl2 / 1.) -15 deg C, 1 h, 2.) 4 deg C, 16 h View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 9 p. 921 - 928
反应条件
1: BOC-glycine With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane 0.166667 h; 2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane 0.333333 h;
参考文献
US2006/161007 A1, ;
Page/Page column 3; 8; Sheet 1 ;
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With trimethylaluminum in hexane; dichloromethane T=-10 - 20°C; 0.5 h; 2: N-tert-butoxycarbonyl glycine methyl ester in hexane; dichloromethane T=0 - 20°C;
参考文献
WO2006/17836 A2, ;
Page/Page column 152-153 ;
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 6 h;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7688 - 7707
反应条件
1: BOC-glycine With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 2 h; 2: N-methoxymethyl amine hydrochloride With triethylamine 3 h; Further stages.;
参考文献
Journal of the Chemical Society, Dalton Transactions, , # 23 p. 3478 - 3488
反应条件
triethylamine in dichloromethane T=0 - 20°C; 1.5 h;
参考文献
Tetrahedron, , vol. 66, # 21 p. 3723 - 3729
反应条件
4-methyl-morpholine in dichloromethane 1.) -15 deg C, 1 h, 2.) 4 deg C, 16 h; Yield given;
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 9 p. 921 - 928
反应条件
in dichloromethane 16 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 76, # 15 p. 6209 - 6217
