7-溴-2,4-二氯吡啶并[3,2-d]嘧啶合成路线 (共 5 条)
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate T=130°C; 10 h;
参考文献
Andaloussi, Mounir; Lim, Herman D.; Van Der Meer, Tiffany; Sijm, Maarten; Poulie, Chris B.M.; De Esch, Iwan J.P.; Leurs, Rob; Smits, Rogier A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2663 - 2670
反应条件
1: sodium hydroxide / 160 °C 2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / toluene / |Heating View Scheme
参考文献
Andaloussi, Mounir; Lim, Herman D.; Van Der Meer, Tiffany; Sijm, Maarten; Poulie, Chris B.M.; De Esch, Iwan J.P.; Leurs, Rob; Smits, Rogier A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2663 - 2670
反应条件
1: hydrogen; ethanol / 14 h / 20 °C 2: sodium hydroxide; water / 5 h / |Reflux 3: 2.5 h / 200 °C 4: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 10 h / 130 °C View Scheme
参考文献
Endo Pharmaceuticals Inc.; Smith, Roger Astbury; Venkatesan, Aranapakam; Bejugam, Mallesham; Hoshalli, Subramanya; Nanduri, Srinivas
Patent: US2014/38952 A1, 2014 ;
反应条件
1: sodium hydroxide; water / 5 h / |Reflux 2: 2.5 h / 200 °C 3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 10 h / 130 °C View Scheme
参考文献
Endo Pharmaceuticals Inc.; Smith, Roger Astbury; Venkatesan, Aranapakam; Bejugam, Mallesham; Hoshalli, Subramanya; Nanduri, Srinivas
Patent: US2014/38952 A1, 2014 ;
反应条件
1: 2.5 h / 200 °C 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 10 h / 130 °C View Scheme
参考文献
Endo Pharmaceuticals Inc.; Smith, Roger Astbury; Venkatesan, Aranapakam; Bejugam, Mallesham; Hoshalli, Subramanya; Nanduri, Srinivas
Patent: US2014/38952 A1, 2014 ;