1-(4-溴苯基)环丙烷羧酸乙酯合成路线 （共 4 条）
反应条件
sulfuric acid T=75°C; 1 h;
参考文献
Amira Phamaceuticals, Inc.
Patent: US2011/82181 A1, 2011 ;
Location in patent: Page/Page column 16 ;
反应条件
1.1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 2.17 h / 20 °C 2.1: potassium hydroxide / ethylene glycol / 4 h / 180 °C 2.2: Acidic conditions 3.1: sulfuric acid / 1 h / 75 °C View Scheme
参考文献
AMIRA PHARMACEUTICALS, INC.; BRISTOL-MYERS SQUIBB COMPANY; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; HUTCHINSON, John, Howard; KING, Christopher, David; ROSSO, Victor, W.
Patent: WO2012/78805 A1, 2012 ;
WO 2012/078805 A1
反应条件
1.1: potassium hydroxide / ethylene glycol / 4 h / 180 °C 1.2: Acidic conditions 2.1: sulfuric acid / 1 h / 75 °C View Scheme
参考文献
AMIRA PHARMACEUTICALS, INC.; BRISTOL-MYERS SQUIBB COMPANY; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; HUTCHINSON, John, Howard; KING, Christopher, David; ROSSO, Victor, W.
Patent: WO2012/78805 A1, 2012 ;
WO 2012/078805 A1
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=80°C; 2 h; Inert atmosphere;
参考文献
Amira Phamaceuticals, Inc.
Patent: US2011/82181 A1, 2011 ;
Location in patent: Page/Page column 16 ;
