5-溴-1H-吡咯并[2,3-C]吡啶合成路线 （共 4 条）
反应条件
1: With iron; acetic acid T=20 - 70°C; 2 h; 2: With sodium hydrogencarbonate
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Yan; HU, Yuandong; WANG, Huting; LIU, Yuliang; LI, Jijun; SUN, Deguang; WANG, Zhe; WEI, Yongheng; WANG, Zanping; TANG, Guojing; JING, Lutao
Patent: WO2012/103806 A1, 2012 ;
Location in patent: Page/Page column 44 ;
WO 2012/103806 A1
反应条件
1: N,N-dimethyl-formamide / 1.5 h / 60 °C / Inert atmosphere 2: lithium aluminium tetrahydride; titanium tetrachloride / tetrahydrofuran / 0.92 h / 20 °C / Inert atmosphere View Scheme
反应条件
1.1: nitric acid; sulfuric acid / 7.75 h / 20 - 50 °C 1.2: pH 9 2.1: copper(I) bromide; tert.-butylnitrite / acetonitrile / 2 h / 60 - 70 °C 3.1: N,N-dimethyl-formamide / 1 h / 100 °C 4.1: acetic acid; iron / 2 h / 20 - 70 °C View Scheme
参考文献
WO2012/103806 A1, ;
WO 2012/103806 A1
反应条件
1: copper(I) bromide; tert.-butylnitrite / acetonitrile / 2 h / 60 - 70 °C 2: N,N-dimethyl-formamide / 1 h / 100 °C 3: acetic acid; iron / 2 h / 20 - 70 °C View Scheme
参考文献
WO2012/103806 A1, ;
WO 2012/103806 A1
