N-[6-(2-氨基苯基氨基)-6-氧代己基]-4-甲基苯甲酰胺; RGFP 109合成路线 （共 5 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane T=0°C; Inert atmosphere;
参考文献
REPLIGEN CORPORATION
Patent: US2012/94971 A1, 2012 ;
Location in patent: Page/Page column 40 ;
反应条件
1: thionyl chloride 2: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 0 - 20 °C 3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere View Scheme
参考文献
REPLIGEN CORPORATION
Patent: US2012/94971 A1, 2012 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 0 - 20 °C 2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere View Scheme
参考文献
REPLIGEN CORPORATION
Patent: US2012/94971 A1, 2012 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 0 - 20 °C 2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere View Scheme
参考文献
REPLIGEN CORPORATION
Patent: US2012/94971 A1, 2012 ;
反应条件
1: lithium hydroxide hydrate 2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere View Scheme
参考文献
REPLIGEN CORPORATION
Patent: US2012/94971 A1, 2012 ;
