4-((1r,2r)-1-(4-氯苯基)-1-羟基-2-戊基)苯甲酸叔丁酯合成路线 （共 5 条）
反应条件
potassium tert-butylate; hydrogen; RuCl2[(S)-xyl-SEGPHOS][(S)-DAIPEN] in isopropyl alcohol
T=20°C; 18 h;
参考文献
MERCK SHARP andamp; DOHME CORP.; LIN, Songnian; STEVENSON, Christian, P.; PARMEE, Emma, R.; XU, Libo; LIAO, Xibin; METZGER, Edward; LIANG, Rui; ZHANG, Fengqi; STELMACH, John, E.
Patent: WO2010/30722 A1, 2010 ;
Location in patent: Page/Page column 39 ;
WO 2010/030722 A1
反应条件
potassium tert-butylate; hydrogen; dichloro[(S)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole][(S)-1,1-bis(4-methoxyphenyl)-3-methylbutane-1,2-diamine]ruthenium(II) in isopropyl alcohol
T=20°C; P=5171.62 Torr; 18 h;
参考文献
MERCK SHARP and; DOHME CORP.; KATS-KAGAN, Roman; STEVENSON, Christian, P.; LIAO, Xibin; FU, Qinghong; PARMEE , Emma, R.; LIN, Songnian
Patent: WO2010/98948 A1, 2010 ;
Location in patent: Page/Page column B ;
WO 2010/098948 A1
反应条件
RuCl2[(S)-(DM-SEGPHOS)][(S)-DAIPEN]; potassium tert-butylate; hydrogen in isopropyl alcohol
T=20 - 25°C; P=4913.04 - 5171.62 Torr; 4 h; Inert atmosphere;
参考文献
Chung, John Y. L.; Steinhuebel, Dietrich; Krska, Shane W.; Hartner, Fred W.; Cai, Chaoxian; Rosen, Jonathan; Mancheno, Danny E.; Pei, Tao; Dimichele, Lisa; Ball, Richard G.; Chen, Cheng-Yi; Tan, Lushi; Alorati, Antony D.; Brewer, Sarah E.; Scott, Jeremy P.
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1832 - 1845
反应条件
1: tetrahydrofuran / 3 h / -5 °C
2: sodium t-butanolate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / tetrahydrofuran / 8 h / 58 - 64 °C / |Inert atmosphere
3: potassium tert-butylate; RuCl2[(S)-(DM-SEGPHOS)][(S)-DAIPEN]; hydrogen / isopropyl alcohol / 4 h / 20 - 25 °C / 4913.04 - 5171.62 Torr / |Inert atmosphere
View Scheme
参考文献
Chung, John Y. L.; Steinhuebel, Dietrich; Krska, Shane W.; Hartner, Fred W.; Cai, Chaoxian; Rosen, Jonathan; Mancheno, Danny E.; Pei, Tao; Dimichele, Lisa; Ball, Richard G.; Chen, Cheng-Yi; Tan, Lushi; Alorati, Antony D.; Brewer, Sarah E.; Scott, Jeremy P.
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1832 - 1845
反应条件
1: sodium t-butanolate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / tetrahydrofuran / 8 h / 58 - 64 °C / |Inert atmosphere
2: potassium tert-butylate; RuCl2[(S)-(DM-SEGPHOS)][(S)-DAIPEN]; hydrogen / isopropyl alcohol / 4 h / 20 - 25 °C / 4913.04 - 5171.62 Torr / |Inert atmosphere
View Scheme
参考文献
Chung, John Y. L.; Steinhuebel, Dietrich; Krska, Shane W.; Hartner, Fred W.; Cai, Chaoxian; Rosen, Jonathan; Mancheno, Danny E.; Pei, Tao; Dimichele, Lisa; Ball, Richard G.; Chen, Cheng-Yi; Tan, Lushi; Alorati, Antony D.; Brewer, Sarah E.; Scott, Jeremy P.
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1832 - 1845
