反应条件
1: 4-(chloromethyl)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 24.5 h; 2: potassium tert-butylate in tetrahydrofuran; tert-butyl methyl ether T=-5 - 10°C; 3: With sodium hydrogencarbonate in tetrahydrofuran; tert-butyl methyl ether; water
参考文献
METABASIS THERAPEUTICS, INC.; GOMEZ-GALENO, Jorge, E.; HECKER, Scott, J.; DANG, Qun; REDDY, Mali Venkat; SUN, Zhili; GROTE, Matthew, P.; NGUYEN, Thanh Huu; LEMUS, Robert, Huerta; LI, Haiqing
Patent: WO2010/19830 A1, 2010 ;
Location in patent: Page/Page column 73-74 ;
WO 2010/019830 A1
