2-环丙基-4-(4-氟苯基)-3-喹啉甲醇合成路线 （共 20 条）
反应条件
water; sodium hydrogencarbonate in acetonitrile 64 h; Reflux;
参考文献
Fabris, Jan; Casar, Zdenko; Smilovic, Ivanagazi
Synthesis (Germany), 2012 , vol. 44, # 11 art. no. SS-2012-T0161-OP, p. 1700 - 1710
反应条件
diisobutylaluminium hydride in toluene T=0°C; 2 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
methanol; sodium tetrahydroborate in tetrahydrofuran T=0 - 5°C; 2 h;
参考文献
WO2012/63254 A1, ;
Page/Page column 9 ;
反应条件
potassium borohydride; magnesium chloride in tetrahydrofuran; toluene T=100°C; 10 h;
参考文献
Qiu, You-Chun; Zhang, Fu-Li; Zhang, Chun-Nian
Tetrahedron Letters, 2007 , vol. 48, # 43 p. 7595 - 7598
反应条件
1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2: DIBAL-H / toluene / 2 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2: DIBAL-H / toluene / 2 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1: toluene-4-sulfonic acid / toluene / 24 h / 105 °C / Sealed reactor 2: N-bromosuccinmide / tetrachloromethane; acetonitrile / 96 h / 20 °C / UV-irradiation 3: water / tetrahydrofuran / 56 h / Reflux View Scheme
反应条件
1: N-bromosuccinmide / tetrachloromethane; acetonitrile / 96 h / 20 °C / UV-irradiation 2: water / tetrahydrofuran / 56 h / Reflux View Scheme
反应条件
1.1: toluene / 0.25 h / 25 °C 1.2: 14 h / 10 - 75 °C / Inert atmosphere 1.3: 0.75 h / 0 - 25 °C / pH 2.5 2.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 2.2: 0.75 h / 0 - 25 °C / pH 6 3.1: diisobutylaluminium hydride / toluene / 2 h / 0 - 25 °C 3.2: 0.25 h / 10 °C View Scheme
反应条件
1.1: phosphorus tribromide / dichloromethane / 1.5 h / 25 °C 1.2: 1 h / 75 °C 2.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C 3.1: water; oxalic acid / methanol / 6 h / 35 °C 3.2: 2.75 h / 10 - 30 °C / pH 7 View Scheme
