2-环丙基-4-(4-氟苯基)-3-喹啉甲醇合成路线 （共 20 条）
反应条件
1.1: DMSO; P2O5; Et3N 2.1: NaOH; (n-octyl)3MeNCl / toluene; H2O 3.1: DIBAH 4.1: NaH; n-BuLi 5.1: NaBH4; Et2BOMe / -78 °C 6.1: aq. NaOH 6.2: (+)-α-methylbenzylamine View Scheme
参考文献
MSN Laboratories Limited
Patent: US2012/16129 A1, 2012 ;
反应条件
sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide T=25°C; Kornblum Oxydation; 56 h;
参考文献
WO2012/13325 A1, ;
Page/Page column 63 ;
反应条件
1: 98 percent / phosphorus tribromide / CH2Cl2; toluene / 3 h / Ambient temperature 2: 100 percent / toluene / 12 h / Heating View Scheme
参考文献
Hiyama; Minami; Takahashi
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 1 p. 364 - 372
反应条件
1: DMSO; P2O5; Et3N 2: NaOH; (n-octyl)3MeNCl / toluene; H2O View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
phosphorus tribromide in dichloromethane; toluene 3 h; Ambient temperature;
参考文献
Hiyama; Minami; Takahashi
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 1 p. 364 - 372
反应条件
1: 98 percent / phosphorus tribromide / CH2Cl2; toluene / 3 h / Ambient temperature 2: 100 percent / toluene / 12 h / Heating 3: 1.) lithium 2,2,6,6-tetramethylpiperidine / 1.) THF, RT, 30 min, 2.) THF, 3 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 68, # 1 p. 364 - 372
反应条件
1.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 2.2: tetrahydrofuran; hexane / -78 °C 3.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C 4.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
1.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 2.2: tetrahydrofuran; hexane / -78 °C 3.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
1.1: phosphorus tribromide / dichloromethane / 3.17 h / 0 - 20 °C 2.1: dichloromethane / Reflux 3.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 80 °C 4.1: (-)-10-CSA / acetonitrile; water / 4 h / 20 °C 5.1: hydrogenchloride / acetonitrile; water / 3 h / 20 °C 5.2: 36 h / 20 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MALLA REDDY, Samala; VAMSI KRISHNA, Bandi
Patent: WO2012/63254 A1, 2012 ;
反应条件
1.1: DMSO; P2O5; Et3N
2.1: NaOH; (n-octyl)3MeNCl / toluene; H2O
3.1: DIBAH
4.1: NaH; n-BuLi
5.1: NaBH4; Et2BOMe / -78 °C
6.1: aq. NaOH
6.2: (-)-α-methylbenzylamine
View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
