2-环丙基-4-(4-氟苯基)喹啉-3-甲醛合成路线 （共 22 条）
反应条件
1: With ozone in methanol T=0 - 5°C; 1 h; 2: With thiourea in water T=0 - 5°C; 1.16667 h;
参考文献
EP1391455 A1, ;
Page 4-5 ;
反应条件
sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide T=25°C; Kornblum Oxydation; 56 h;
参考文献
WO2012/13325 A1, ;
Page/Page column 63 ;
反应条件
sulfuric acid in tetrahydrofuran; toluene
反应条件
1: toluene-4-sulfonic acid / toluene / 24 h / 105 °C / Sealed reactor 2: N-bromosuccinmide / tetrachloromethane; acetonitrile / 96 h / 20 °C / UV-irradiation 3: water / tetrahydrofuran / 56 h / Reflux 4: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 56 h / 25 °C View Scheme
反应条件
1: water / tetrahydrofuran / 56 h / Reflux 2: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 56 h / 25 °C View Scheme
反应条件
1: N-bromosuccinmide / tetrachloromethane; acetonitrile / 96 h / 20 °C / UV-irradiation 2: water / tetrahydrofuran / 56 h / Reflux 3: sodium hydrogencarbonate; dimethyl sulfoxide / sodium iodide / 56 h / 25 °C View Scheme
反应条件
1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2: DIBAL-H / toluene / 2 h / 0 °C 3: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2: DIBAL-H / toluene / 2 h / 0 °C 3: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1: DIBAL-H / toluene / 2 h / 0 °C 2: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 5 °C 2: phosphorus tribromide / dichloromethane / 3.17 h / 0 - 20 °C 3: dichloromethane / Reflux 4: potassium carbonate / N,N-dimethyl-formamide / 20 - 80 °C 5: (-)-10-CSA / acetonitrile; water / 4 h / 20 °C View Scheme
