2-环丙基-4-(4-氟苯基)喹啉-3-甲醛合成路线 （共 22 条）
反应条件
1.1: NaOH; (n-octyl)3MeNCl / toluene; H2O 2.1: DIBAH 3.1: NaH; n-BuLi 4.1: NaBH4; Et2BOMe / -78 °C 5.1: aq. NaOH 5.2: (+)-α-methylbenzylamine View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
methanol; sodium tetrahydroborate in tetrahydrofuran T=0 - 5°C; 2 h;
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MALLA REDDY, Samala; VAMSI KRISHNA, Bandi
Patent: WO2012/63254 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
sodium hydroxide; Aliquatreg; 336 in water; toluene Condensation; Emmons-Horner reaction;
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 5 °C 2: phosphorus tribromide / dichloromethane / 3.17 h / 0 - 20 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MALLA REDDY, Samala; VAMSI KRISHNA, Bandi
Patent: WO2012/63254 A1, 2012 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 1.2: tetrahydrofuran; hexane / -78 °C 2.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C 3.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
sodium hydride in tetrahydrofuran T=63°C; 11 h; Product distribution / selectivity;
参考文献
Nissan Chemical Industries, Ltd.
Patent: EP1614682 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium hydride in tetrahydrofuran T=63°C; 11 h; Product distribution / selectivity;
参考文献
Nissan Chemical Industries, Ltd.
Patent: EP1614682 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium hydride in tetrahydrofuran T=63°C; 11 h; Product distribution / selectivity;
参考文献
Nissan Chemical Industries, Ltd.
Patent: EP1614682 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 1.2: tetrahydrofuran; hexane / -78 °C 2.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C View Scheme
参考文献
AUROBINDO PHARMA LIMITED; NANDI, Sukumar; GONA, Balanarasimha Reddy; AKKINA, Naresh; GORIMELLA, Narayan Krishna Anjaneya Subramanya Sambho; KOILPILLAI, Joseph Prabahar; MEENAKSHISUNDERAM, Sivakumaran
Patent: WO2012/140490 A2, 2012 ;
反应条件
1.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h / 0 - 5 °C 2.1: phosphorus tribromide / dichloromethane / 3.17 h / 0 - 20 °C 3.1: dichloromethane / Reflux 4.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 80 °C 5.1: (-)-10-CSA / acetonitrile; water / 4 h / 20 °C 6.1: hydrogenchloride / acetonitrile; water / 3 h / 20 °C 6.2: 36 h / 20 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MALLA REDDY, Samala; VAMSI KRISHNA, Bandi
Patent: WO2012/63254 A1, 2012 ;
