1-苄基-1H-吲哚-2,3-二酮合成路线 （共 11 条）
反应条件
sodium hydroxide; sodium ethanolate 1) toluene, RT, 20 h; 2) 80-90 deg C, 5-10 min; Yield given. Multistep reaction;
参考文献
Baiocchi, Leandro; Giannangeli, Marilena
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1905 - 1909
反应条件
1: With dihydrogen peroxide; sodium hydroxide in water T=30°C; Cooling with ice; 2: With acetic acid in water pH=5 - 6; Cooling with ice;
参考文献
Wang, Yao; Zhang, Mei; Cao, Shengli; Lin, Huihui; Gao, Man; Li, Zhongfeng
Synthetic Communications, 2012 , vol. 42, # 18 p. 2715 - 2727
反应条件
hydrogenchloride; sodium hydroxide; sodium nitrite 2.) 5 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Baiocchi,Leandro; Picconi, Giuseppe
Tetrahedron Letters, 1983 , vol. 24, # 34 p. 3651 - 3652
反应条件
hydrogenchloride; sodium hydroxide; sodium nitrite 2.) 5 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Baiocchi,Leandro; Picconi, Giuseppe
Tetrahedron Letters, 1983 , vol. 24, # 34 p. 3651 - 3652
反应条件
1: 88 percent / tetrahydrofuran / 1 h / 0 °C 2: 67 percent / BF3*OEt2; Et3SiH / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Trost, Barry M.; Xie, Jia; Sieber, Joshua D.
Journal of the American Chemical Society, 2011 , vol. 133, # 50 p. 20611 - 20622
反应条件
potassium carbonate 0.5 h; microwave irradiation;
参考文献
El Ashry, El Sayed H.; Ramadan, El Sayed; Abdel Hamid, Hamida M.; Hagar, Mohamed
Synlett, 2004 , # 4 p. 723 - 725
反应条件
1: 92 percent / AcOH / ethanol / 2.5 h / microwave irradiation 2: 64 percent / aq. K2CO3 / microwave irradiation View Scheme
参考文献
El Ashry, El Sayed H.; Ramadan, El Sayed; Abdel Hamid, Hamida M.; Hagar, Mohamed
Synlett, 2004 , # 4 p. 723 - 725
反应条件
sodium hydroxide; sodium ethanolate 1) toluene, RT, 20 h; 2) 80-90 deg C, 5-10 min; Yield given. Multistep reaction;
参考文献
Baiocchi, Leandro; Giannangeli, Marilena
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1905 - 1909
反应条件
1: 58 percent / 1) sodium ethylate; 2) 5N sodium hydroxide / 1) toluene, RT, 20 h; 2) 80-90 deg C, 5-10 min
2: Heating
View Scheme
参考文献
Baiocchi, Leandro; Giannangeli, Marilena
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1905 - 1909
反应条件
NH2NH2•xH2O
T=130°C; Wolff-Kishner reduction; 3 h; Inert atmosphere;
参考文献
Horne, David A.; Jove, Richard; Lincoln, Christopher; Nam, Sangkil; Overman, Larry; Xie, Jun
Patent: US2013/225637 A1, 2013 ;
Location in patent: Paragraph 0138-0139 ;
