反应条件
1: (1R,4R)-1,1-Dimethylethyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate With hydrogenchloride in 1,4-dioxane T=20°C; 1 h; 2: benzyl chloroformate With triethylamine in dichloromethane T=20°C; 2.16667 h;
参考文献
INTERVET INTERNATIONAL B.V.; DE VITA, Robert, J.; HONG, QingMei; LAI, Zhong; DYKSTRA, Kevin, D.; YU, Yang; LIU, Jian; SPERBECK, Donald; JIAN, Tianying; GUIADEEN, Deodial; XU-QIANG YANG, Ginger; WU, Zhicai; HE, Shuwen; TING, Pauline, C.; ASLANIAN, Robert; KUETHE, Jeffrey, T.; BALKOVEC, James, M.; KUANG, Rongze; ZHOU, Gang; WU, Heping
Patent: WO2012/164071 A1, 2012 ;
Location in patent: Page/Page column 98-99 ;
WO 2012/164071 A1
