反应条件
1: 4-(N,N-dimethlyamino)pyridine / N,N-dimethyl-formamide / 18 h / 0 - 60 °C
2: potassium carbonate; tri-cyclo-hexyl-phosphine / palladium diacetate / isobutyramide / 1 h / 140 °C / Inert atmosphere; Biotage microwave reactor
View Scheme
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
WO 2011/112731 A2
