1: 81 percent / N-methylmorpholine, tert-butyl hypochlorite / toluene / 1.) from -40- -50 deg C to RT, 3 h; 2.) 2 h 2: 65 percent / Mg / methanol / 4 h / 30 °C 3: 83 percent / 80 percent aq. acetic acid / 0.5 h / 50 °C 4: 96 percent / Et3N / various solvent(s) / 24 h / 50 °C 5: 78 percent / 4 mol dm-3 HCl / dioxane / 16 h / Ambient temperature View Scheme

1: 81 percent / N-methylmorpholine, tert-butyl hypochlorite / toluene / 1.) from -40- -50 deg C to RT, 3 h; 2.) 2 h 2: 65 percent / Mg / methanol / 4 h / 30 °C 3: 83 percent / 80 percent aq. acetic acid / 0.5 h / 50 °C View Scheme

With  magnesium in  methanol T=30°C; 4 h;   

With  4-methyl-morpholine; tert-butylhypochlorite in  toluene  1.) from -40- -50 deg C to RT, 3 h; 2.) 2 h;   

With  magnesium in  methanol T=30°C; 4 h;   

Multi-step reaction with 2 steps 1: 81 percent / N-methylmorpholine, tert-butyl hypochlorite / toluene / 1.) from -40- -50 deg C to RT, 3 h; 2.) 2 h2: 65 percent / Mg / methanol / 4 h / 30 °C