1217428-98-2合成路线 （共 10 条）
反应条件
boron trifluoride diethyl etherate Heating;
参考文献
Gregory,G.I. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 47 - 51
反应条件
1: With N-ethyl-N,N-diisopropylamine in dichloromethane T=-15 - 20°C; 2: With pyridine 20 h; RefluxSealed tube;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 193 ;
WO 2010/142801 A1
反应条件
in pyridine T=20°C; 6 h; Heating / reflux;
参考文献
Kolb, Hartmuth C.; Kanamarlapudi, Ramanaiah C.; Richardson, Paul F.
Patent: US2004/19215 A1, 2004 ;
Location in patent: Page 5 ;
反应条件
1: N-tert-butoxycarbonyl-β-alanine With 1,1'-carbonyldiimidazole in tetrahydrofuran T=0 - 20°C; 1 h; 2: EtOCOC(NH2)NOH With pyridine in tetrahydrofuran 2 h; Heating / reflux;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2006/62224 A1, 2006 ;
Location in patent: Page/Page column 64 ;
反应条件
1: EtOCOC(NH2)NOH With diisopropylamine in dichloromethane T=-10°C; 0.166667 h; 2: chloroacetyl chloride in dichloromethane T=-10 - 20°C; 3: in toluene 12 h; Reflux;
参考文献
ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB; NADIN, Alan, John; OSBOURN, Susan, Elizabeth; TISSELLI, Patrizia; RAY, Nicholas, Charles
Patent: WO2010/18352 A1, 2010 ;
Location in patent: Page/Page column 38 ;
WO 2010/018352 A1
参考文献
Kissinger; Ungnade
Journal of Organic Chemistry, 1958 , vol. 23, p. 1517
反应条件
in pyridine 1.5 h; Heating; Yield given;
参考文献
Borg, Susanna; Estenne-Bouhtou, Genevieve; Luthman, Kristina; Csoeregh, Ingeborg; Hesselink, Willy; Hacksell, Uli
Journal of Organic Chemistry, 1995 , vol. 60, # 10 p. 3112 - 3120
反应条件
1: With pyridine 1 h; Heating / reflux; 2: With sodium tetrahydroborate in methanol
参考文献
Ghosh, Arun K.; Lei, Hui; Devasamudram, Thippeswamy; Tang, Jordan J. N.; Bilcer, Geoffrey; Liu, Chungfeng
Patent: US2008/125467 A1, 2008 ;
Location in patent: Page/Page column 21 ;
反应条件
ammonium nitrate; nitric acid
参考文献
Ungnade; Kissinger
Journal of Organic Chemistry, 1959 , vol. 24, p. 666
参考文献
Ungnade; Kissinger
Journal of Organic Chemistry, 1959 , vol. 24, p. 666
