in tetrahydrofuran; water T=60°C; 2.5 h;

triethylamine in N,N-dimethyl-formamide T=20°C; 15 h;

1.1: n-butyllithium / 2-methyl tetrahydrofuran / 1.5 h / -40 - -30 °C 1.2: 6 h / -30 - 20 °C 1.3: 1.67 h / 0 - 25 °C 2.1: sodium hydroxide / ethanol / 12 h / 78 °C 3.1: hydrogen fluoride; sulfur(IV) fluoride 4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -15 °C 4.2: 1.5 h / -15 °C 4.3: 0.42 h / 10 - 20 °C / pH 2 - 4 5.1: N-bromosuccinmide / toluene; ethanol / 1.5 h / 40 °C 6.1: pyridine / tetrahydrofuran / 1.5 h / 40 °C 7.1: water; tetrahydrofuran / 2.5 h / 60 °C View Scheme

1.1: sodium acetate / dimethyl sulfoxide / 20 - 25 °C 2.1: potassium carbonate; methanol / 1 h / 20 °C 3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.32 h / 0 - 40 °C 3.2: 20 - 40 °C 4.1: cyclohexane; hexane / 3.25 h / 10 - 20 °C 5.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -15 °C 5.2: 1.5 h / -15 °C 5.3: 0.42 h / 10 - 20 °C / pH 2 - 4 6.1: N-bromosuccinmide / toluene; ethanol / 1.5 h / 40 °C 7.1: pyridine / tetrahydrofuran / 1.5 h / 40 °C 8.1: water; tetrahydrofuran / 2.5 h / 60 °C View Scheme

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -15 °C 1.2: 1.5 h / -15 °C 1.3: 0.42 h / 10 - 20 °C / pH 2 - 4 2.1: N-bromosuccinmide / toluene; ethanol / 1.5 h / 40 °C 3.1: pyridine / tetrahydrofuran / 1.5 h / 40 °C 4.1: water; tetrahydrofuran / 2.5 h / 60 °C View Scheme

1: N-bromosuccinmide / toluene; ethanol / 1.5 h / 40 °C 2: pyridine / tetrahydrofuran / 1.5 h / 40 °C 3: water; tetrahydrofuran / 2.5 h / 60 °C View Scheme

1.1: potassium carbonate; methanol / 1 h / 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.32 h / 0 - 40 °C 2.2: 20 - 40 °C 3.1: cyclohexane; hexane / 3.25 h / 10 - 20 °C 4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -15 °C 4.2: 1.5 h / -15 °C 4.3: 0.42 h / 10 - 20 °C / pH 2 - 4 5.1: N-bromosuccinmide / toluene; ethanol / 1.5 h / 40 °C 6.1: pyridine / tetrahydrofuran / 1.5 h / 40 °C 7.1: water; tetrahydrofuran / 2.5 h / 60 °C View Scheme

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.32 h / 0 - 40 °C 1.2: 20 - 40 °C 2.1: cyclohexane; hexane / 3.25 h / 10 - 20 °C 3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -15 °C 3.2: 1.5 h / -15 °C 3.3: 0.42 h / 10 - 20 °C / pH 2 - 4 4.1: N-bromosuccinmide / toluene; ethanol / 1.5 h / 40 °C 5.1: pyridine / tetrahydrofuran / 1.5 h / 40 °C 6.1: water; tetrahydrofuran / 2.5 h / 60 °C View Scheme

1.1: cyclohexane; hexane / 3.25 h / 10 - 20 °C 2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -15 °C 2.2: 1.5 h / -15 °C 2.3: 0.42 h / 10 - 20 °C / pH 2 - 4 3.1: N-bromosuccinmide / toluene; ethanol / 1.5 h / 40 °C 4.1: pyridine / tetrahydrofuran / 1.5 h / 40 °C 5.1: water; tetrahydrofuran / 2.5 h / 60 °C View Scheme

1.1: sodium hydroxide / ethanol / 12 h / 78 °C 2.1: hydrogen fluoride; sulfur(IV) fluoride 3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -15 °C 3.2: 1.5 h / -15 °C 3.3: 0.42 h / 10 - 20 °C / pH 2 - 4 4.1: N-bromosuccinmide / toluene; ethanol / 1.5 h / 40 °C 5.1: pyridine / tetrahydrofuran / 1.5 h / 40 °C 6.1: water; tetrahydrofuran / 2.5 h / 60 °C View Scheme