3-(1,3-二恶烷-2-基)-1-(4-甲氧基苯基)-1-丙酮合成路线 （共 7 条）
反应条件
ammonium chloride; magnesium in tetrahydrofuran
参考文献
Matsumoto, Takahiro; Katayama, Nozomi; Mabuchi, Hiroshi
Patent: US2003/144338 A1, 2003 ;
反应条件
in tetrahydrofuran T=-78 - 20°C;
参考文献
KARO BIO AB; WENNERSTAaL, Mattias; LOeFSTEDT, Joakim; WU, Xiongyu; KRUeGER, Lars; HAGBERG, Lars
Patent: WO2011/42477 A1, 2011 ;
Location in patent: Page/Page column 40; 41 ;
WO 2011/042477 A1
反应条件
1: 81 percent / KOH / methanol; H2O / 4 h / Heating 2: thionyl chloride / 1 h / Heating 3: 1.) Mg / 1.) THF, 30 min, reflux; 2.) THF, 12 h, room temperature View Scheme
参考文献
Laatsch, Hartmut; Pudleiner, Heinz
Liebigs Annalen der Chemie, 1989 , p. 863 - 882
反应条件
1: K2CO3 / acetone / 12 h / Heating 2: 81 percent / KOH / methanol; H2O / 4 h / Heating 3: thionyl chloride / 1 h / Heating 4: 1.) Mg / 1.) THF, 30 min, reflux; 2.) THF, 12 h, room temperature View Scheme
参考文献
Laatsch, Hartmut; Pudleiner, Heinz
Liebigs Annalen der Chemie, 1989 , p. 863 - 882
反应条件
1: pyridine / dichloromethane / 0 - 20 °C 2: tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
KARO BIO AB; WENNERSTAaL, Mattias; LOeFSTEDT, Joakim; WU, Xiongyu; KRUeGER, Lars; HAGBERG, Lars
Patent: WO2011/42477 A1, 2011 ;
WO 2011/042477 A1
反应条件
1: thionyl chloride / 1 h / Heating 2: 1.) Mg / 1.) THF, 30 min, reflux; 2.) THF, 12 h, room temperature View Scheme
参考文献
Laatsch, Hartmut; Pudleiner, Heinz
Liebigs Annalen der Chemie, 1989 , p. 863 - 882
反应条件
magnesium 1.) THF, 30 min, reflux; 2.) THF, 12 h, room temperature; Yield given. Multistep reaction;
参考文献
Laatsch, Hartmut; Pudleiner, Heinz
Liebigs Annalen der Chemie, 1989 , p. 863 - 882
