2-(2-硝基亚乙基氨基)苯甲酸合成路线 （共 17 条）
参考文献
DE347375 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 521
反应条件
hydrogenchloride in water 18 h; Ambient temperature;
参考文献
Nicholson, John R.; Singh, Gurdial; McCullough, Kevin J.; Wightman, Richard H.
Tetrahedron, 1989 , vol. 45, # 3 p. 889 - 908
参考文献
Goeblyoes, Aniko; Gao, Zhan-Guo; Brussee, Johannes; Connestari, Roberto; Santiago, Sabrina Neves; Ye, Kai; Ijzerman, Adriaan P.; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3354 - 3361
参考文献
Journal of Organic Chemistry, , vol. 25, p. 1312 - 1322
参考文献
Journal of Organic Chemistry, , vol. 25, p. 1312 - 1322
反应条件
1: 49 percent / Ac2O; CH3COOK 2: 81 percent / POCl3 View Scheme
参考文献
Bachman et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 365,370
反应条件
1: 49 percent / Ac2O; CH3COOK 2: 81 percent / POCl3 3: 95 percent / NH3 View Scheme
参考文献
Goeblyoes, Aniko; Gao, Zhan-Guo; Brussee, Johannes; Connestari, Roberto; Santiago, Sabrina Neves; Ye, Kai; Ijzerman, Adriaan P.; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 11 p. 3354 - 3361
反应条件
potassium acetate; acetic anhydride
参考文献
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES; UNIVERSITEIT LEIDEN
Patent: WO2007/89507 A1, 2007 ;
Location in patent: Page/Page column 20 ;
WO 2007/089507 A1
反应条件
1.1: acetic anhydride; sodium acetate / 0.25 h / |Reflux 2.1: hydrogen; platinum on carbon / N,N-dimethyl-formamide / 3.5 h / 3102.97 Torr 3.1: triethylamine / N,N-dimethyl-formamide; dichloromethane / 0 °C 4.1: pyridine; tetraphosphorus decasulfide / 2 h / |Reflux 5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 18 h / 20 °C 6.1: benzoyl isocyanate / dichloromethane / 0.5 h / |Reflux 6.2: 2 h / |Reflux View Scheme
参考文献
Kokatla, Hari Prasad; Yoo, Euna; Salunke, Deepak B.; Sil, Diptesh; Ng, Cameron F.; Balakrishna, Rajalakshmi; Malladi, Subbalakshmi S.; Fox, Lauren M.; David, Sunil A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1179 - 1198
反应条件
1: 1.) Ac2O, 2.) NaOAc / 1.) reflux, 1 h, 2.) a) 100 deg C, b) 25 deg C, overnight 2: PCl5, POCl3 / Heating 3: N2H4*H2O / propan-2-ol / 20 h / Ambient temperature View Scheme
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
