5-氯噻唑并[5,4-b]吡啶-2(1h)-酮合成路线 （共 3 条）
反应条件
water; hydrogenchloride in 1,4-dioxane T=95°C; 0.333333 h; oil bathInert atmosphere;
参考文献
MERCK SHARP and DOHME CORP.; LAYTON, Mark, E.; KELLY, Michael, J.
Patent: WO2011/137046 A1, 2011 ;
Location in patent: Page/Page column 29 ;
WO 2011/137046 A1
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 3.5 h / 170 °C / oil bath; Inert atmosphere 1.2: 20 °C / pH 5 2.1: potassium carbonate / tetrahydrofuran / 0.08 h / 20 °C / Sealed vessel 3.1: dichloromethane; methanol / 18 h / 20 °C / Inert atmosphere 4.1: water / hydrogenchloride / 1,4-dioxane / 0.33 h / 95 °C / oil bath; Inert atmosphere View Scheme
参考文献
MERCK SHARP and DOHME CORP.; LAYTON, Mark, E.; KELLY, Michael, J.
Patent: WO2011/137046 A1, 2011 ;
WO 2011/137046 A1
参考文献
Yamamoto
Yakugaku Zasshi, 1951 , vol. 71, p. 916,919
Chem.Abstr., 1952 , p. 8109
