2-(2,5-二氟苯基)吡咯烷合成路线 （共 3 条）
反应条件
sodium hydroxide in water; ethyl acetate
参考文献
ARRAY BIOPHARMA INC.; ANDREWS, Steven, W.; HAAS, Julia; JIANG, Yutong; ZHANG, Gan
Patent: WO2010/33941 A1, 2010 ;
Location in patent: Page/Page column 34 ;
WO 2010/033941 A1
反应条件
1.1: sec.-butyllithium; (-)-sparteine / cyclohexane; tert-butyl methyl ether / 3 h / -78 - -70 °C
1.2: 0.5 h / -78 - 20 °C
1.3: 20 °C
2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
3.1: sodium hydroxide / ethyl acetate; water
View Scheme
参考文献
ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven S.; CONDROSKI, Kevin Ronald; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; SEO, Jeongbeob
Patent: WO2011/6074 A1, 2011 ;
反应条件
1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
2: sodium hydroxide / ethyl acetate; water
View Scheme
参考文献
ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven S.; CONDROSKI, Kevin Ronald; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; SEO, Jeongbeob
Patent: WO2011/6074 A1, 2011 ;
