sodium hydroxide in water; ethyl acetate

With  hydrogenchloride in  1,4-dioxane T=20°C; 2 h;  Show Experimental Procedure  

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102551', constants.ctx, '0')">1,4-dioxane</a> <br />T=20&deg;C;&nbsp;2&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: sec.-butyllithium; (-)-sparteine / cyclohexane; tert-butyl methyl ether / 3 h / -78 - -70 &deg;C<br />1.2: 0.5 h / -78 - 20 &deg;C<br />1.3: 20 &deg;C<br />2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 &deg;C<br /> <br /> &nbsp;