3,4,5,6-四氢-2H-[1,4]双吡啶-4-羧酸乙酯合成路线 （共 7 条）
反应条件
thionyl chloride T=50°C;
参考文献
Ajinomoto Co., Inc.
Patent: EP2311810 A1, 2011 ;
Location in patent: Page/Page column 21 ;
反应条件
triethylamine in ethanol T=120°C; 48 h;
参考文献
AJINOMOTO CO., INC.
Patent: US2002/193348 A1, 2002 ;
US 20020193348 A1
反应条件
1: 90 percent / Et3N / ethanol; H2O / 96 h / 150 °C 2: 78 percent / thionyl chloride / ethanol / 1) 20 min, 0 deg C, 2) 2 h, room temp., 3) 2 h, reflux View Scheme
参考文献
Guendouz, Farida; Jacquier, Robert; Verducci, Jean
Tetrahedron, 1988 , vol. 44, # 23 p. 7095 - 7108
反应条件
1: 90 percent / Et3N / ethanol; H2O / 96 h / 150 °C 2: 78 percent / thionyl chloride / ethanol / 1) 20 min, 0 deg C, 2) 2 h, room temp., 3) 2 h, reflux View Scheme
参考文献
Guendouz, Farida; Jacquier, Robert; Verducci, Jean
Tetrahedron, 1988 , vol. 44, # 23 p. 7095 - 7108
反应条件
triethylamine T=150°C; 48 h;
参考文献
Guendouz, Farida; Jacquier, Robert
Tetrahedron Letters, 1984 , vol. 25, # 40 p. 4521 - 4524
反应条件
sodium hydroxide in ethanol Reflux;
参考文献
De Candia, Modesto; Fiorella, Filomena; Lopopolo, Gianfranco; Carotti, Andrea; Romano, Maria Rosaria; Lograno, Marcello Diego; Martel, Sophie; Carrupt, Pierre-Alain; Belviso, Benny D.; Caliandro, Rocco; Altomare, Cosimo
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8696 - 8711
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 4 h; Cooling with ice; 2: With water; sodium hydroxide in tetrahydrofuran T=20°C; Cooling with ice;
参考文献
Ajinomoto Co., Inc.
Patent: EP2311810 A1, 2011 ;
Location in patent: Page/Page column 21 ;
