吡啶, 2-[(二氟甲基)磺酰基]-合成路线 （共 19 条）
反应条件
1: potassium hydroxide 2: (NH4)6Mo7O24*4H2O; dihydrogen peroxide / methanol / 36 h / 20 °C View Scheme
参考文献
Zhou, Qianghui; Ruffoni, Alessandro; Gianatassio, Ryan; Fujiwara, Yuta; Sella, Eran; Shabat, Doron; Baran, Phil S.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 14 p. 3949 - 3952
Angew. Chem., 2013 , vol. 125, # 14 p. 4041 - 4044,4
反应条件
1: With potassium tert-butylate in N,N-dimethyl-formamide T=-50 - -40°C; Julia-Kocienski type gem-difluoroolefination; 0.25 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
1: With potassium tert-butylate in N,N-dimethyl-formamide T=-50 - -40°C; Julia-Kocienski type gem-difluoroolefination; 0.25 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
1: With potassium tert-butylate in N,N-dimethyl-formamide T=-50 - -40°C; Julia-Kocienski type gem-difluoroolefination; 0.25 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
1: With potassium tert-butylate in N,N-dimethyl-formamide T=-50 - -40°C; Julia-Kocienski type gem-difluoroolefination; 0.25 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
1: With potassium tert-butylate in N,N-dimethyl-formamide T=-50 - -40°C; Julia-Kocienski type gem-difluoroolefination; 0.25 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
1: With potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide T=-50 - -20°C; Julia-Kocienski type gem-difluoroolefination; 3 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in tetrahydrofuran; N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
1: With potassium tert-butylate in N,N-dimethyl-formamide T=-50 - -40°C; Julia-Kocienski type gem-difluoroolefination; 0.25 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
1: With potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide T=-50 - -20°C; Julia-Kocienski type gem-difluoroolefination; 3 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in tetrahydrofuran; N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
1: With potassium tert-butylate in N,N-dimethyl-formamide T=-50 - -40°C; Julia-Kocienski type gem-difluoroolefination; 0.25 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
