(2R)-羟基(2-甲氧基苯基)乙腈合成路线 （共 32 条）
反应条件
1: ortho-anisaldehyde With DOWER(R)50WX4 in acetonitrile T=20°C; 0.0833333 h; 2: sodium cyanide in acetonitrile T=20°C; 2 h;
参考文献
Sofighaderi, Sargol; Setamdideh, Davood
Oriental Journal of Chemistry, 2013 , vol. 29, # 3 p. 1135 - 1137
反应条件
in diethyl ether; acetic acid T=0 - 20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/76423 A2, 2007 ;
Location in patent: Page/Page column 60 ;
WO 2007/076423 A2
反应条件
1: With tetra-n-butylammonium alginate in toluene T=20°C; 24 h; Inert atmosphere; 2: With hydrogenchloride; water in methanol; toluene
参考文献
Verrier, Cecile; Oudeyer, Sylvain; Dez, Isabelle; Levacher, Vincent
Tetrahedron Letters, 2012 , vol. 53, # 15 p. 1958 - 1960
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Akagawa, Kengo; Kudo, Kazuaki
Tetrahedron Letters, 2012 , vol. 53, # 45 p. 5981 - 5983,3
Title/Abstract Full Text Show Details
Akagawa, Kengo; Kudo, Kazuaki
Tetrahedron Letters, 2012 , vol. 53, # 45 p. 5981 - 5983
反应条件
zirconium tetra-t-butoxide in dichloromethane; toluene T=20°C; Meerwein-Ponndorf-Verley cyanation; 5 h;
参考文献
Ooi, Takashi; Takaya, Keisuke; Miura, Tomoya; Maruoka, Keiji
Synlett, 2000 , # 1 p. 69 - 70
反应条件
hydrogenchloride in ethanol; water 2 h; Ambient temperature;
参考文献
Yamaguchi; Uchiuzoh; Sanada
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 2 p. 419 - 423
反应条件
di-n-butyltin dimethoxide in diethyl ether T=20°C; 20 h; Inert atmosphere;
参考文献
Yanagisawa, Akira; Matsumoto, Takuya; Kushihara, Naoyuki; Yoshida, Kazuhiro
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 17 p. 2918 - 2922
反应条件
4-(N,N-dimethlyamino)pyridine; vanadium triisopropoxide oxide in acetonitrile T=25°C; 48 h; Inert atmosphere;
参考文献
Kodama, Koichi; Kawamata, Hiroaki; Takahashi, Naoya; Hirose, Takuji
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 47 p. 9440 - 9446
反应条件
1: 1,3-bis(methylsulfonyl)-1H-imidazol-3-ium chloride; potassium tert-butoxide / tetrahydrofuran / 1.5 h / 20 °C 2: aq. HCl / tetrahydrofuran View Scheme
参考文献
Zhang, Zhiguo; Lippert, Katharina M.; Hausmann, Heike; Kotke, Mike; Schreiner, Peter R.
Journal of Organic Chemistry, 2011 , vol. 76, # 23 p. 9764 - 9776
反应条件
1: 80 percent / 8.5percent NaOH / 45 °C 2: 75 percent / diethyl ether / 0 °C View Scheme
参考文献
Ghosh, Somnath; Datta, Indira; Chakraborty, Rupak; Das, Tapas Kumar; Sengupta, Judhajit; Sarkar, Dipak Chandra
Tetrahedron, 1989 , vol. 45, # 5 p. 1441 - 1446
