1: 4-chloro-benzoyl chloride; phenylacetylene With copper(l) iodide; Pd2(PPh3)2Cl2; triethylamine in tetrahydrofuran
T=20°C; Sonogashira coupling-Michael addition-cyclocondensation-sulfur extrusion; 1 h; Inert atmosphereCombinatorial reaction / High throughput screening (HTS);
2: 2-amino-benzenethiol With acetic acid in tetrahydrofuran; isopropyl alcohol
T=150°C; Sonogashira coupling-Michael addition-cyclocondensation-sulfur extrusion; 1 h; Microwave irradiationInert atmosphereCombinatorial reaction / High throughput screening (HTS); regiospecific reaction;
参考文献
Rotzoll, Sven; Willy, Benjamin; Schoenhaber, Jan; Rominger, Frank; Mueller, Thomas J. J.
European Journal of Organic Chemistry, 2010 , # 18 p. 3516 - 3524