1-(叔丁氧基羰基)-2-甲基-3-氧代哌啶-2-羧酸合成路线 （共 3 条）
反应条件
1: 93 percent / conc. ammonia, H2 / rhodium on carbon / H2O / 21 h / 2585.7 Torr 2: 90 percent / HCl / Heating 3: 66 percent / NaHCO3, NaCl / H2O; CHCl3 / 1) 6 h, reflux, 2) overnight, r.t. 4: 86 percent / oxalyl chloride, dimethyl sulfoxide / CH2Cl2 / 0.25 h View Scheme
参考文献
Drummond, J.; Johnson, G.; Nickell, D. G.; Ortwine, D. F.; Bruns, R. F.; Welbaum, B.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2116 - 2128
反应条件
potassium tert-butylate in toluene 0.166667 h;
参考文献
Knight, David W.; Lewis, Neil; Share, Andrew C.; Haigh, David
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3673 - 3683
反应条件
1: 66 percent / NaHCO3, NaCl / H2O; CHCl3 / 1) 6 h, reflux, 2) overnight, r.t. 2: 86 percent / oxalyl chloride, dimethyl sulfoxide / CH2Cl2 / 0.25 h View Scheme
参考文献
Drummond, J.; Johnson, G.; Nickell, D. G.; Ortwine, D. F.; Bruns, R. F.; Welbaum, B.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2116 - 2128
