[5-(2-二甲基氨基乙基)-8-甲基-2-(4-甲基苯基)-4-氧代-2,3-二氢-1,5-苯并硫氮杂卓-3-基]乙酸酯合成路线 （共 3 条）
反应条件
1: 90.8 percent / aq. NaOH / 24 h / Heating 2: 13.2 percent / 15 h / 150 - 160 °C 3: pyridine / 7 h / Ambient temperature 4: 82 percent / aq. NaOH / tetrahydrofuran; methanol / 0.5 h / Ambient temperature 5: 94.8 percent / aq. K2CO3 / acetone / Heating 6: pyridine / 100 - 110 °C View Scheme
参考文献
Inoue, Hirozumi; Konda, Mikihiko; Hashiyama, Tomiki; Otsuka, Hisao; Watanabe, Akishige; Gaino, Mitsunori; Takahashi, Kaoru; Date, Tadamasa; Okamura, Kimio; Takeda, Mikio; Narita, Hiroshi; Murata, Sakae; Odawara, Akio; Sasaki, Haruhiko; Nagao, Taku
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 6 p. 1008 - 1026
反应条件
1: 13.2 percent / 15 h / 150 - 160 °C 2: pyridine / 7 h / Ambient temperature 3: 82 percent / aq. NaOH / tetrahydrofuran; methanol / 0.5 h / Ambient temperature 4: 94.8 percent / aq. K2CO3 / acetone / Heating 5: pyridine / 100 - 110 °C View Scheme
参考文献
Inoue, Hirozumi; Konda, Mikihiko; Hashiyama, Tomiki; Otsuka, Hisao; Watanabe, Akishige; Gaino, Mitsunori; Takahashi, Kaoru; Date, Tadamasa; Okamura, Kimio; Takeda, Mikio; Narita, Hiroshi; Murata, Sakae; Odawara, Akio; Sasaki, Haruhiko; Nagao, Taku
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 6 p. 1008 - 1026
反应条件
pyridine T=100 - 110°C;
参考文献
Inoue, Hirozumi; Konda, Mikihiko; Hashiyama, Tomiki; Otsuka, Hisao; Watanabe, Akishige; Gaino, Mitsunori; Takahashi, Kaoru; Date, Tadamasa; Okamura, Kimio; Takeda, Mikio; Narita, Hiroshi; Murata, Sakae; Odawara, Akio; Sasaki, Haruhiko; Nagao, Taku
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 6 p. 1008 - 1026
