4-溴-2,3,5,6-四氟苯甲酰氯合成路线 （共 2 条）
反应条件
phosphorus pentachloride Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2531 - 2540
反应条件
1: 86 percent / BuLi
2: tetrahydrofuran / Ambient temperature
3: tetrahydrofuran / 1 h
4: 62 percent / K2CO3 / dimethylformamide / 1.5 h / 150 °C
5: 43 percent / HMPA, PdCl2(PPh3)2 / tetrahydrofuran / 24 h / Heating
6: 76 percent / NaH / tetrahydrofuran
7: 62 percent / Raney nickel / ethanol / 0.25 h / Heating
8: 75 percent / 1 M aq. HCl / 2 h / Heating
View Scheme
参考文献
Reuman, Michael; Daum, Sol J.; Singh, Baldev; Wentland, Mark P.; Perni, Robert B.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2531 - 2540
