1: tetrahydrofuran / Ambient temperature 2: tetrahydrofuran / 1 h 3: 62 percent / K2CO3 / dimethylformamide / 1.5 h / 150 °C 4: 43 percent / HMPA, PdCl2(PPh3)2 / tetrahydrofuran / 24 h / Heating 5: 76 percent / NaH / tetrahydrofuran 6: 62 percent / Raney nickel / ethanol / 0.25 h / Heating 7: 75 percent / 1 M aq. HCl / 2 h / Heating View Scheme

Multi-step reaction with 5 steps 1: tetrahydrofuran / Ambient temperature2: tetrahydrofuran / 1 h3: 62 percent / K2CO3 / dimethylformamide / 1.5 h / 150 °C4: 43 percent / HMPA, PdCl2(PPh3)2 / tetrahydrofuran / 24 h / Heating5: 94 percent / NaH / tetrahydrofuran