3,4-二甲基联苯-4-羧酸合成路线 (共 2 条)
反应条件
1: With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water 5 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/34277 A1, 2007 ;
Location in patent: Page/Page column 54-55 ;
反应条件
sodium hydroxide in ethanol T=60°C; 2 h;
参考文献
Tilley; Clader; Zawoiski; Wirkus; LeMahieu; O'Donnell; Crowley; Welton
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1814 - 1820