3,4-二甲氧基联苯-4-羧酸合成路线 （共 5 条）
反应条件
sodium hydroxide in ethanol
T=60°C; 2 h;
参考文献
Tilley; Clader; Zawoiski; Wirkus; LeMahieu; O'Donnell; Crowley; Welton
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1814 - 1820
反应条件
sodium hydroxide in tetrahydrofuran
2 h; Ambient temperature;
参考文献
Klein, Scott I.; Czekaj, Mark; Gardner, Charles J.; Guertin, Kevin R.; Cheney, Daniel L.; Spada, Alfred P.; Bolton, Scott A.; Brown, Karen; Colussi, Dennis; Heran, Christopher L.; Morgan, Suzanne R.; Leadley, Robert J.; Dunwiddie, Christopher T.; Perrone, Mark H.; Chu, Valeria
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 437 - 450
反应条件
1: 1.) n-BuLi, 2.) ZnCl2, 3.) (Ph3P)2PdCl2, (i-Bu)2AlH
2: aq. NaOH / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Klein, Scott I.; Czekaj, Mark; Gardner, Charles J.; Guertin, Kevin R.; Cheney, Daniel L.; Spada, Alfred P.; Bolton, Scott A.; Brown, Karen; Colussi, Dennis; Heran, Christopher L.; Morgan, Suzanne R.; Leadley, Robert J.; Dunwiddie, Christopher T.; Perrone, Mark H.; Chu, Valeria
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 437 - 450
反应条件
1: 1.) n-BuLi, 2.) ZnCl2, 3.) (Ph3P)2PdCl2, (i-Bu)2AlH
2: aq. NaOH / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Klein, Scott I.; Czekaj, Mark; Gardner, Charles J.; Guertin, Kevin R.; Cheney, Daniel L.; Spada, Alfred P.; Bolton, Scott A.; Brown, Karen; Colussi, Dennis; Heran, Christopher L.; Morgan, Suzanne R.; Leadley, Robert J.; Dunwiddie, Christopher T.; Perrone, Mark H.; Chu, Valeria
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 437 - 450
反应条件
2: 55 percent / 30percent NaOH / ethanol / 2 h / 60 °C
View Scheme
参考文献
Tilley; Clader; Zawoiski; Wirkus; LeMahieu; O'Donnell; Crowley; Welton
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1814 - 1820
