1-[(三甲基甲硅烷基)甲基]苯并三唑合成路线 （共 7 条）
反应条件
1: 1,2,3-Benzotriazole With sodium methylate in methanol 2: chloromethyl-trimethyl-silane With 18-crown-6 ether in N,N-dimethyl-formamide
参考文献
Roman, Bart I.; Ryck, Tine De; Dierickx, Laura; Vanhoecke, Barbara W.A.; Katritzky, Alan R.; Bracke, Marc; Stevens, Christian V.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4812 - 4819
反应条件
18-crown-6 ether in N,N-dimethyl-formamide T=25 - 30°C;
参考文献
Trofimova; Brodskaya; Bolgova; Chernov; Voronkov
Doklady Chemistry, 2003 , vol. 388, # 1-3 p. 26 - 29
反应条件
sodium hydroxide in ethanol; N,N-dimethyl-formamide Ambient temperature;
参考文献
Katritzky, Alan R.; Offerman, Rick J.; Cabildo, Pilar; Soleiman, Mohammed
Recueil des Travaux Chimiques des Pays-Bas, 1988 , vol. 107, # 11 p. 641 - 646
反应条件
sodium hydride in N,N-dimethyl-formamide 1.) 0 deg C, 10 min, 2.) RT, 1.75 h;
参考文献
Johnson, A. Peter; Dutton, Jonathan K.; Pleynet, David P. M.
Heterocycles, 1994 , vol. 37, # 3 p. 1913 - 1932
反应条件
1: 1.) LDA / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT, 2h, c) RT, overnight 2: 1.) n-BuLi, 2.) Mg, 1,2-dibromoethane 3: 40 percent / acetonitrile / 2.75 h / Irradiation View Scheme
参考文献
Johnson, A. Peter; Dutton, Jonathan K.; Pleynet, David P. M.
Heterocycles, 1994 , vol. 37, # 3 p. 1913 - 1932
反应条件
in diethyl ether T=20°C;
参考文献
Katritzky, Alan R.; Vvedensky, Vladimir Y.; Tymoshenko, Dmytro O.
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 19 p. 2483 - 2486
反应条件
in tetrahydrofuran
Condensation; 24 h; Heating;
参考文献
Katritzky; Zhang; Haleem; Hussein; Fang; Steel
Journal of Organic Chemistry, 2001 , vol. 66, # 16 p. 5606 - 5612
