potassium carbonate in N,N-dimethyl-formamide T=90 - 100°C; 15 h;

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere 1.2: 0 - 80 °C / Inert atmosphere 2.1: sodium methylate / methanol / -8 - 5 °C 3.1: anhydrous xylene / 6.33 h / Reflux 4.1: water; sodium hydroxide / ethanol / 12 h / 20 °C View Scheme